Is there a cunning trick to setting things to the mouse wheel scroll? I tried to set acceleration to the wheel. After clicking on the bind, where it's waiting for input, rotating the wheel doesn't register - clicking the middle button does, but not the ol' wheely scroller...
I don't really know if you can have a scroll up/down bind. The way I do it is left click to accelerate, right click to decelerate. It takes about a week to get used to, but not having to take my fingers off the steering wasd commands to change throttle is useful.
Another pro tip for captains, just take the E key to dismount completely off. Use space to get off helm, it'll take away the freak E hits and all of a sudden you're off helm in the middle of a fight.
I have my map bound to Q, can't even begin to say how useful this is to be able to hit it with one hand and not reach for M. I put the task list to T, because chances are I don't really need to see it right away, so I don't mind reaching a bit for that key.
Lastly, I use a push-to-talk setup for TeamSpeak when I'm playing with my clan, and I bind it to my mouse 4 button (aka the back button for a browser). If you use any outside of game voice feature, it might be a good idea for ya too.