If you have a fancy mouse with tons of extra buttons, you probably are very used to remapping keys to it in every game. Unfortunately I have a standard office-style mouse and keyboard. 2 mouse buttons and a scroll wheel. And I cannot push more than 5 or so keys at once, or the keyboard becomes unresponsive.
The following setup works very well for me as a pilot. It requires only a few re-binds to strongly prevent accidentally leaving the hull. It helps with 'key limit' (pressing too many keys at once) on a standard keyboard. It also makes the map very accessible on the left hand without giving up any mobility. Plus, it means more frantic mouse clicking for the pilot, and everyone knows ... more clicking = more fun.
For pilot:
Throttle up to left mouse
Throttle down right mouse
Global:
Map to Q or ALT
A variant I played around with was "car pedal" style, decelerate on left and accelerate on right. I didn't like it.
But thats it. Makes a world of difference.