My go to ship, the Junker. My pride and joy, The Cloud Whaler.
With a chain gun on the UL and a Flak on the LL I've been able to chew through most opposition, even with the newbies I like to fly with when the terrible sky tyrant turns into the magic school bus.
On my right side and bowsprit I try to keep it fluid, or as needed.
Merc/Artemis is a tasty combination, with a banshee rocking the front. I've also tried flame and barker for that up in your grill kill. What's big for me is captain tools on this beast; kerosene is often a must, along with my tar that I can't live without. I'll adjust the fit depending on the opposition, such as some lionfish spitting rocket death at me, well that'll be chutes and hydrogen to keep me out of that things arc.
For squids I like to have tar and a Phoenix claw, as they love getting into my rear and I almost feel obliged to make the squid feel at home in a cloud of ink before I turn hard and bring a chain gun and flak into its face.
Galleons I'm loathe to take toe to toe, preferring to deal the killing blow while other ships soak up hits. Same goes for pyramidions, I'm not fond of them getting close to me.